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The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program

Potential breaking of weight-loss plateaus, especially when standard diet/exercise alone have slowed

Patients should be directed toward evidence-based alternatives for metabolic optimization

The same research group, in a separate 2001 publication by Heffernan et al

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