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doi:10.1158/0008-5472.CAN-05-0808 Coriat R, Nicco C, Chreau C et al (2012) Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo

VD: OR = 0.902, p = 0.436)

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IR causes erythrocytes to extravasate to surrounding tissues and heme-iron is released via macrophage-mediated hemolysis in tissues, which is subsequently degraded to ferrous iron and other constituents [42]