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Despite compelling data, awareness of the link between smoking and liver disease remains suboptimal among healthcare providers and the general public

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Glutamate homeostasis and neurotransmission play a major role in the onset of depression and anxiety

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In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]