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Substrates are compounds that contain a nucleophilic heteroatom (nitrogen, sulfur) presenting a lone pair of electrons

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However, since these patients are often deficient in vitamin B12, injectable B12 in the form of hydroxycobalamin is often chosen as part of their treatment

After receiving the patients informed consent, we began the following treatment in July 2019: Combined therapy with oral antioxidants propolis 700 mg + bilberry 180 mg + silymarin 400 mg + ginkgo biloba 240 mg + L-carnitine 1000 mg + coenzyme Q10 100 mg + Boswellia 200 mg + vitamin E 48 mg + vitamin C 50 mg + superoxide dismutase 11,000 IU/g 10 mg/daily + topical diclofenac gel 4%/2 daily + peri-plaque penile injection of pentoxifylline 100 mg with 30 G needle every month for 12 months

We also assessed for independent association of CC ratio with these outcomes using a MV regression model including age, sex, BMI, and MELD-Na as covariates