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for instance, physical exercise can stimulate VEGF expression, 310,311 leading to cellular level changes, such as stimulation of angiogenesis, increased delivery of neurotrophic factors and oxygen by the vascular system, 312 an increase in the neurogenesis rate and induction of synaptogenesis

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Acute pancreatitis promotes the expression of NO and inducible nitric oxide synthase (iNOS), which activates the NF-B signaling pathway, and mediates the increase induced by spinal cord cyclooxygenase-2 (COX-2) via IL-1, and stimulates pain in the body [101]

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