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5.2 Therapeutic efficacy in animal models 5.2.1 Neurodegenerative disorders Several compounds have demonstrated significant therapeutic potential in animal models of neurodegenerative diseases, such as AD and PD (Wang et al., 2022)

Short-term use of the lowest effective dose may be a reasonable option for patients with occasional or infrequent need or those who have not responded to safer therapies, but close monitoring for augmentation and other side effects is essential (Winkelman 2025)

primates e.g., humans, monkeys, apes, gibbons, chimpanzees, orangutans, macaques and the like an animal may be a transgenic animal

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