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Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)

The Comfort-in needle-free injection system is an excellent alternative to needle-based syringes and is an effective and convenient method for B12 needle-free delivery

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These observations clearly highlight the critical need for more accurate and predictive microphysiological systems (MPS) that better mimic the human liver environment to eliminate false positive and false negative DILI as early as possible in the drug development process