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10.3389/fphar.2016.00479 48 GaoL.ZhangQ.LiS.ZhengJ.RenW.ZhiK

Zinc: Zinc is an essential nutrient that is involved in many body functions

Ferritinophagy releases iron through its selective cargo receptor, nuclear receptor coactivator 4 (NCOA4), providing bioavailable iron for cellular and mitochondrial functions

62 In addition, after fluoxetine-mediated stimulation of the 5-HT 2B receptor in astrocytes, epidermal growth factor receptor (EGFR) is transactivated and subsequently activates the MAPK/ERK and PI3K/AKT signaling cascades, which control the expression of mRNA or proteins that may be linked to mood disorders, such as SERT