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Material and Methods The methodology and reporting conducted in this review are based on the guidelines recommended by the Cochrane Collaboration in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins et al., 2021)

This combination approach allows for targeted treatment of problem areas like the face or neck while providing whole-body benefits through injection

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Hansen et al [17] used Hanks Balanced Salt Solution (HBSS) containing 5% FCS and 2 mM EDTA for both, while Cervantes-Barragan et al [15] replaced the HBSS with PBS and Luckashenak et al [16] used PBS for suspending the cells and HBSS for diluting the OptiPrep (both containing 0.2% BSA and 2 mM EDTA

Meanwhile, endogenous carriers demonstrate inherent advantages in biocompatibility