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CosMx pseudobulk DE genes were analyzed using DESeq2 to compare non-responders to responders pre-treatment 76

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33 The clinical efficacy of SAM in the treatment of cholestasis associated with hepatic diseases has been reviewed

It was further shown that p53 promotes ferroptosis under various ferroptosis-inducing conditions partly by repressing SLC7A11 expression, whereas SLC7A11 upregulation by p53 deficiency promotes ferroptosis resistance (Jiang et al., 2015)

APAP induced CD45 + cell infiltration in both groups, with no significant difference between genotypes (Fig