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In addition, AMPK agonist GSK621 up-regulated the protein levels of LC3B and Beclin1, and further increased the level of ferroptosis, which could be antagonized by GPX3 overexpression

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Therefore, despite being only a partial effector of carcinogenesis, CBS belongs to a panel of intervening players, including NF-B, KRAS, p53 and Wnt components, that contribute to metabolic rewiring and increased proliferative and invasive potential