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A depurao ocorre principalmente por degradao enzimtica por peptidases sricas e teciduais

Pain 159 , 469480 (2018)

If unfolded proteins continue to accumulate in the ER, GRP78 (also known as BIP) can be released from inositol-requiring kinase/endonuclease 1 (IRE1), activating transcription factor 6 (ATF6) and protein kinase activated by PERK

Comparative effects of doxorubicin and a doxorubicin analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on human topoisomerase II activity and cardiac function in a chronic rabbit model

do Nascimento Remigio AF, Salles AG, de Faria JCM, Ferreira MC (2015) Comparison of the efficacy of OnabotulinumtoxinA and abobotulinumtoxina at the 1: 3 conversion ratio for the treatment of asymmetry after long-term facial paralysis