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The lactams 33 and 34 comprising 14-membered ring systems were most active in the series but nonetheless 100-fold less potent than the best disulfide and carba analogues (Barlow et al., 2020)

10.1056/nejm196105042641801

After six months of treatment, patients showed a significant increase in the number of hairs per square centimeter and an increase in hair thickness

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