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[66] GABA enhances the catabolism of serotonin into N -acetylserotonin (the precursor of melatonin) in rat pineal glands (removed from the body, ex vivo )

Chen Y-K, Hsueh Y-P

R., Lau, A

And the endocannabinoid system where CBD works may be the linchpin: In this biological context, endocannabinoids are released to retain NMDAR activity within physiological limits