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NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors

10.1038/s41588-020-00776-w 319 ScialoF.SriramA.StefanatosR.SpriggsR

The trial, while showing that high doses are well tolerated when used for a short time, did not produce positive effects on general respiratory health, lung function, or circulating measures of systemic oxidative stress and inflammation [55]

Thus, doxorubicin, a potent anticancer drug, but with heavy side effects, was delivered in association with chemically immobilized bromelain, by lactobionic acid-modified chitosan NPs

The default settings for the SZMAP and Gameplan applications were used in all the calculations