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The present work intended to assess the neuroprotective and remyelinating effects of FIS in mice with CPZ-induced demyelination and its influence on modulating ferroptosis pathway which is interconnected to oxidative stress as a detrimental cell death modality in MS pathology

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doi: 10.1074/jbc.M111.238147

Compared with WT mice, hGRK4 142V mice have increased phosphorylation of renal ETBR and AdipoR1 and impaired ETBR- and AdipoR1-induced diuresis and natriuresis [21, 82]