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c , Drug synergy analysis of data shown in (a) using the ZIP model

J Pharm Sci 86(3):378383 Sugibayashi K, Hayashi T, Morimoto Y (1999) Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: the effect of enzyme distribution in skin

Phase 2 data reported roughly 10-11% weight loss versus placebo at ~26 weeks as a monotherapy example, and Phase 3 CagriSema data reported substantially larger reductions when combined with semaglutide

Screen patients for risk of substance use disorders, including opioid abuse and misuse, and warn them of the risk for overdose and death associated with the use of additional CNS depressants including alcohol and illicit drugs [see PRECAUTIONS: Drug Interactions, Information for Patients]

*Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement