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Environ Health Perspect 1983, 49:5969

Cancer 12 , e008554 (2024)

The expression of GPX4 in Tregs is essential for resisting oxidative stress within the TME ( TAMs TAMs are the most abundant innate immune cells in the TME, comprising pro-tumorigenic M2 macrophages and pro-inflammatory, antitumorigenic M1 macrophages (74)

For laboratory studies and diagnosing resistance mechanisms, other synergists employed include S,S,S-tributyl phosphorotrithioate (DEF) and triphenyl phosphate (TPP), which inhibit ESTs [134, 135], and Diethyl Maleate (DEM) and ethacrynic acid (EA) are both used to inhibit GSTs [136, 137]