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[The Working Group noted that this was a semiquantitative histopathological analysis, that the descriptions of inflammation appeared to be inconsistent, and that portal vein congestion may be an artefact since this outcome is often seen in rats that have not been completely exsanguinated

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Early (red) marks respond well to lasers or microneedling started sooner Older (white) marks improve more gradually

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Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies