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Phase I enzymes like cytochromes P450 (CYP) or carboxylesterases catalyze the biotransformation of apolar odorants resulting in phase I metabolites carrying functional groups (OH, NH 2 , COOH)

440 Energy metabolism during ischemiareperfusion injury Ischemiareperfusion injury occurs when blood flow restoration to the heart exacerbates dysfunction and structural damage instead of recovery (Fig

However, the relationship between the p62/Keap1/Nrf2 signaling pathway and ferroptosis in hypoxia-related diseases still needs further research, and is a potential direction for future research

doi: 10.1016/j.jhep.2021.07.035 42 AlvarezCSGraubardBIThistleJEPetrickJLMcGlynnKA

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