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These conditions offer a robust justification for novel plans to improve the efficacy of mAbs targeting tumor vasculature, such as antibodydrug conjugates (ADCs) and peptide-drug conjugates (PDCs), offering a new avenue to exert anti-angiogenic effects on cancerous cells

Deep and superficial vein thrombosis, Ischaemic lower leg due to peripheral vascular disease, thromboembolism or thrombosed popliteal aneurysm Traumatic muscle and tendon injuries such as calf muscle tear and / or haematoma (gastrocnemius, soleus or plantaris most commonly) and Achilles rupture Infective causes such as cellulitis or abscess formation Soft tissue tumours Referred radicular / neuropathic pain (sciatica)

doi: 10.1016/j.cellsig.2016.02.010

Beware of B12 analogues Some foods contain so-called B12 analogues molecules that are almost the same as B12 but not quite

The combination of pemetrexed and cisplatin may extend life expectancy for patients