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Koch H, van Bokhoven MA, ter Riet G, et al

People deficient in B12 often experience fatigue and lack physical and mental stamina

Functional Assessments Range of motion testing measured with a goniometer at consistent intervals (weekly) Pain scales standardized VAS (visual analog scale) scores, recorded at the same time of day Strength testing grip strength, manual muscle testing, or machine-based measurement Gait analysis for lower extremity injuries, tracking stride length and symmetry GI symptom diaries for gut-related applications, daily tracking of symptoms (bloating, pain, stool quality) Biomarkers CRP (C-reactive protein) systemic inflammation marker

Consistent with the PAMPA measurements, the 1,8-diMQ analogue exhibited very low bi-directional transport in the Caco-2 cell assay (Table 2)

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