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From the residues known to be active in the interaction of GSH with previously-determined structures of Musca domestica epsilon-GST (PDB Nilaparvata lugens delta-GST (PDB: and sigma-GST (PDB: the putative binding sites of S

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In this respect, it is notable that the expression of GSK3 and the phosphorylation of glycogen synthase (GS), which is the substrate of GSK3beta, were decreased in the liver extracts of MLK3 KO mice upon APAP treatment, which implies that MLK3 is connected to GSK3 through a positive feedback loop in APAP-induced liver injury 33

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