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J Drug Res Ayurvedic Sci

BSO depletes cellular GSH [10] and sensitizes tumor cells to apoptosis induced by standard chemotherapeutic agents [15, 16]

These guidelines synthesize evidence from multiple trials and provide recommendations on patient selection, dosing, monitoring, and combination therapy strategies

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The studies above confirm that catalpol reduces osteoclast activity and improves osteogenic differentiation in bone diseases primarily through pathways such as Wnt/-catenin, JAK2/STAT3, miR-124-3p/DNMT3b/TRAF6, and Sirt6/Er/FasL (Table 7