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It has been found that high levels of VIC may be associated with the development of kidney stones, as one of the metabolites of VIC is oxalate

388 Nrf2 inhibition Nrf2, frequently overexpressed in therapy-resistant cancers, represents a promising therapeutic target for ROS-mediated anticancer strategies, as demonstrated by Tamoxifen-resistant breast cancer cells that develop irradiation cross-resistance through Nrf2-driven antioxidant upregulation and a glycolytic shift, with Nrf2 inhibition restoring radiosensitivity in both cellular models and patient tumors (NCT00738777)

10.1016/j.jnutbio.2012.05.003 63 YantL

15 Arterial thrombosis causes reduced blood flow (ischemia), resulting in reduced oxygen and nutrient delivery and ischemic tissue damage

Comet assay for DNA damage Cells in culture were untreated (DMSO, control) or treated with R001 at the indicated concentrations for 24 h, or in the case of H 2 O 2 (400 M), cells were treated for 1 h