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As increased cytotoxicity upon loss of NUPR1 has been suggested to be mediated through ferroptosis 43,44,45,46 , apoptosis and necrosis 47,48,49 , depending on cell type and context, we assessed pro- and anti-ferroptotic readouts upon NUPR1 inhibition in our culture system

Mesenchymal stem cell-seeded high-density collagen gel for annular repair: 6-week results from in vivo sheep models

10.1038/s41598-019-47582-x Sci

This elevation reduces ROS-induced DNA damage and improves the rates of first polar body extrusion from 48.9% to 75.7% ( in vitro supplementation of CoQ10 has been shown to mitigate the decline of these proteins attributable to aging ( CoQ10 and ovarian aging The process of ovarian aging is marked by a gradual decline in mitochondrial function, which affects both somatic and germ cells in the ovary (Tesarik et al., 2021)

Hypertension 81 , e41e43 (2024)