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Translational Psychiatry , 11(1), 15

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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development

The evolutionary maintenance of an extra sodC gene copy indicates that SOD is essential for pathogenic bacteria for their survival inside the host niche [101]

Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T: Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration