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Obesity is prevalent in approximately 40% of PCOS patients, with 70% of obese individuals exhibiting at least one abnormal lipid parameter ( Figure 1 2 Factors affecting the occurrence and development of PCOS The pathogenesis of PCOS is multifactorial, involving genetic predisposition, metabolic dysregulation, endocrine abnormalities, immune imbalance, and environmental influences, all of which interact to contribute to the disease phenotype

When disc material herniates, it triggers an inflammatory cascade involving cytokines, prostaglandins, and other chemical mediators

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