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The malignancy of pancreatic cancer is high and the 5-year survival rate of PDAC is as low as 10% ( PDAC is characterized by a high (up to 95%) mutation rate in the Kirsten rat sarcoma virus oncogene homolog ( KRAS ) gene

10.1002/cbin.11222 56 DebayleM.BalloulE.DembeleF.XuX.HanafiM.RibotF.et al (2019)

Discussion We have identified compounds ( 1 - 10 ) that act as non-covalent inhibitors of TGR with druglike properties as demonstrated by efficacy in mice infected with S

Umeda R, Teranishi H, Hada K, Shimizu N, Shiraishi H, Urushibata H, et al

Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile