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The main signaling pathways downstream of the IGF-1 receptor are Ras/MAPK and PI3K/Akt, while these two pathways are responsible for the glucose and lipid metabolism in the liver ( Crosstalk Between Circadian Clock System and GH/IGF-1 Axis Regulatory Effect of the GH/IGF-1 Axis on the Circadian Clock System There are very few reports to identify the regulatory effect of the GH/IGF-1 axis on the circadian clock system

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24 and 23 provided data to weeks 12 and 24 respectively

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As will be discussed later, SAHF play key roles in maintaining the senescent state, suppressing tumorigenesis, and influencing cell fate

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Glycocalyx degradation can also lead to atelectasis

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38 , e70087 (2025)

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