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Individuals with certain polymorphisms of these genes will usually require a lower dose of warfarin to maintain a therapeutic INR, as well as need a longer time to achieve a stable dose

So dividing your desired dose by the concentration gives you the fraction of a milliliter you need, and multiplying by 100 converts that to syringe units

doi: 10.1056/NEJMoa1706450 14 BardiaAHurvitzSATolaneySMLoiratDPunieKOliveiraMet al

however, it offers the advantage of compatibility with traditional collection tubes and allows for the collection of a larger sample volume (up to 600 L), which is beneficial for biomedical analyses (Jacobson et al