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We revealed that various concentrations of the PI3K inhibitor LY294002 and Akt inhibitor MK-2206 2HCL suppressed the up-regulation of miR-146a-3p levels induced by GHK in a concentration-dependent manner (Figures 6B,C)

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It has been proposed that RBC hemolysis products (heme, hemin and iron) induce the generation of reactive oxygen species (ROS) such as superoxide radicals and hydrogen peroxide 35 and that ROS are believed to affect platelet function and promote platelet activation both directly through the action of superoxide radicals, and indirectly through nitric oxide inhibition which contributes to platelet aggregation and thrombus formation 36

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Dietary hydroxyproline promotes collagen deposition in swim bladder through regulating biosynthesis of amino acid: In-vitro and in-vivo investigations in Nibea coibor