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in NP-MSCs, the combined effect of hypoxia and nutrient deprivation inhibits cell proliferation, induces apoptosis, enhances caspase-3 activity, and downregulates functional genes (e.g., proteoglycan, collagen-I and -II) and stem cell-related genes (including Oct4, Nanog, Jagged, and Notch1) (Tian et al., 2020)

96 The disruption of normal protein phosphorylation and dephosphorylation processes can have various cellular effects, including alterations in the cytoskeleton, cell cycle progression, and apoptosis