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Pro-inflammatory immune cells (M1 macrophages, Th17 cells, neutrophils) promote ferroptosis via iron accumulation, lipid peroxidation, and ROS production

BIOACTIVATION OF CANCER COMPOUNDS BY GST Glutathione transferases (EC 2.5.1.18) are a superfamily of dimeric detoxification enzymes which contribute to the cellular biotransformation of electrophilic compounds (Mannervik et al., 2005)

Sickle cell disease induces chromatin introversion and ferroptosis in Cd8(+) T cells to suppress anti-tumor immunity

In a rat model of acetic acid-induced gastric ulcers, rhamnogalacturonan-I type pectic polysaccharide of black cumin can mediate ulcer healing by modulating signaling pathways involved in either ulcer aggravation or healing process [199]

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