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All procedures involving animals were performed in accordance with the ethical standards and according to the Declaration of Helsinki and to national guidelines approved by the ethical committee of Animal Welfare Office of Italian Health Ministry (aut

Among these, carnosine (-alanyl-L-histidine) treatment, at a maximal non-cytotoxic concentration (10 mM), significantly reduced NO bioavailability without affecting intracellular superoxide levels, while improving cellular energy status, as shown by increased ATP/ADP ratio and elevated cellular energy charge

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Myelin production, oligodendrocytes and Zn Zn is also critical for the development of oligodendrocytes (161, 211214)

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