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2 Preclinical and mechanistic evidence of TCM active constituents in PD We conducted a narrative appraisal of study-design features as reported in the included articles, noting the presence or absence of randomization, blinding, allocation concealment, sample-size justification, outcome-assessor masking, selective reporting, and funding or conflicts of interest

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LOX and its related proteins utilize copper ions to catalyze the oxidative deamination of lysine residues, promoting the cross-linking of collagen and elastin [101,102,103]