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Complexation of dihydroxybenzoic acids with metals can prevent hydrolysis [1] [2] and affect the mobility and bioavailability of the metals

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5.6 Increased Risk of Toxicity with Ibuprofen in Patients with Renal Impairment Exposure to pemetrexed is increased in patients with mild to moderate renal impairment who take concomitant ibuprofen, increasing the risks of adverse reactions of pemetrexed

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