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Serum ferritin: past, present and future

Removal of these inclusions by the spleen generates pitted, rigid cells that have shortened life spans, producing hemolytic anemia of variable severity, sometimes requiring chronic transfusion support

Similar to HDACi, the aim is therefore to use wisely designed combination treatments to synergistically enhance the effect of well-established anti-cancer drugs through HDACi (Gnyszka et al., 2013)