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doi: 10.1038/s41419020-033624 58 BelavgeniAMeyerCStumpfJHugoCLinkermannA

In vitro studies have demonstrated that NRTIs also have the potential to incorporate into nuclear and mitochondrial DNA and inhibit host DNA polymerases and induce DNA damage 174,175,176,177

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As such, these results suggest that the redox potential in the nucleus remains stable across all phases of the cell cycle, irrespective of structural and morphological changes associated with mitosis