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TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages

This analysis identified upregulated proteins, mainly chloroplast chaperonins such as Chaperonin-60 and

PloS One (2013) 8(11):e78507

In our study, MTX was shown to significantly elevate MDA levels while reducing GSH levels in liver tissues, contributing to oxidative stress and the formation of lipid peroxides as observed in other studies