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Sulforaphane can support osteoblast differentiation ( via epigenetic mechanisms) and expression of the osteoclast activator receptor activator of nuclear factor-B ligand (RANKL) in osteocytes (Thaler et al., 2016)

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A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed