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Pattern recognition receptors, including toll-like receptors (TLRs), may display species-specific differences in expression levels and functional activity, which in turn influences the efficiency of virus detection and downstream signaling pathways

that translation requires further RCT evidence

Fletcher, R

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20 Induction of necroptosis after treatment with APR-246 in our cells was excluded due to the absence of protection by more specific necroptosis inhibitors (Necrostatin 1s and Necrosulfonamide), 21 , 22 and due to the absence of MLKL phosphorylation, a key marker in necroptosis 21 ( Online Supplementary Figure S1A and B )