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Typical cationic moieties include quaternary ammonium, protonated ammonium, imidazolines, amines, diamines, Sulfonium, and phosphonium moieties

In congenital pernicious anemia, low serum total B12 concentrations arise from B12 malabsorption caused by mutations in a gene (GIF,CBLIF) and defects in the synthesis of intrinsic factor