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Side Effects Allergic reactions (rash, swelling, breathing difficulties) Digestive issues (nausea, diarrhea) Hormonal imbalances (if overusing growth-related peptides) Increased blood sugar or blood pressure (with certain peptides like GHRPs) 2

This burden is disproportionately heavier in low- and middle-income countries (LMICs), where underdiagnosis, limited therapeutic access, and healthcare disparities amplify disease impact (Payami et al., 2023

Stratification by BMI showed a trend toward higher responsiveness (increased diversity and evenness) to the pasteurized sauerkraut intervention among overweight participants (Supplementary Fig