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370 In hyperglycemic states, changes in the metabolic pathways of sugar (increased flux of the hexosamine pathway, increased flux of the polyol pathway, decreased flux of pentose phosphate and glycolytic pathways) lead to decreased production of NADPH and increased ROS, exacerbating oxidative stress

MacKenzie T, Comi R, Sluss P, Keisari R, Manwar S, Kim J et al (2007) Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial

Traditionally the left and right panels are tilted slightly, allowing for a completely enveloping environment but in all cases this causes visible image warping

10.1016/j.cell.2019.04.012 [DOI] [PMC free article] [PubMed] [Google Scholar] 403