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Description

How dying cells alert the immune system to danger

2011;6(3):e18059

Zhang J, Hu W, Ding C, Yao G, Zhao H, Wu S

Miao C, Wang X, Zhou W, Huang J

By interfering with these processes, chemotherapeutic medications can cause ER stress and an accumulation of unfolded or misfolded proteins in the ER lumen that triggers the unfolded protein response (UPR), a signalling network that aims to restore ER homeostasis