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Patients should be informed of the pros and cons of oral versus parenteral therapy, and regardless of the form of treatment, those with pernicious anemia or malabsorption should be reminded of the need for lifelong replacement

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By blocking NNMT, it prevents the methylation and degradation of nicotinamide, increasing the substrate available for NAD+ synthesis

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This is partly due to its role in energy metabolism and gastrointestinal health