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In mice pretreated with buthionine sulfoxime to inhibit GSH synthesis and induce a deficient state, oral administration of GSH resulted in statistically significant increases in GSH concentrations in kidney, heart, lung, brain, small intestine, and skin, but not in the liver

In a clinical trial, an adverse event is any untoward medical occurrence that is experienced by a trial participant which is not necessarily related to the intervention [12]

By mediating the entry of drug molecules, these transporters significantly influence drug bioavailability and therapeutic efficacy

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