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[DOI] [PubMed] [Google Scholar] 56.Wegrowski Y, Maquart FX, Borel JP

Neuropsychiatric disorders are also characterized by important sex differences, and accumulating evidence supports sex differences in the pharmacokinetics and pharmacodynamics of many drugs that act on the brain

Changes in BBB integrity, endothelial receptor and transporter function, vascular dysfunction, amyloid burden, and neuroinflammatory status can influence nanoparticle penetration, biodistribution, cellular uptake, and target engagement (Haqqani et al., 2024)