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The researchers showed that blocking glutamine metabolism through JHU083 not only suppressed tumor cell metabolism but also mitigated the tumor microenvironment, which is hostile to the immune response due to its hypoxic, acidic, and nutrient-depleted conditions, unleashing the natural antitumor T cell response

Acknowledgements Kodirov is grateful to his mentor, Vladimir Leonidovich Zhuravlev 71 (Leningrad University, USSR), for the introduction to the comparative science field

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